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KMID : 0948320080080010015
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Konyang Medical Journal
2008 Volume.8 No. 1 p.15 ~ p.19
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Necessity of Ultrasonography Guided Fine-Needle Aspiration or Core Biopsy for Benign-Looking Malignant Thyroid Nodules
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Yoo Hyeun-Mi
Hwang Cheol-Mog
Kim Keum-Won
Park Yong-Sung
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Abstract
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Purpose: To analyze the frequency of benign-looking malignant thyroid nodules and to evaluate the usefulness of
ultrasonography guided fine-needle aspiration and core biopsy.
Materials and Methods : Two radiologists retrospectively analyzed in consensus the sonographic features of pathologically proven 392 malignant thyroid nodules of 378 patients. The patients underwent ultrasonography guided fine-needle aspiration biopsy, ultrasonography guided core biopsy, or surgery. We analyzed the following five sonographic features of thyroid nodule; internal content, margin, echogenicity, shape, and microcalcification based on previous reports. We determined thyroid nodules as benign-looking malignant nodules in cases that they showed no ultrasonographic malignant feature or below two ultrasonographic malignant features. We calculated the frequency of the benign-looking malignant nodule.
Results: The benign-looking malignant nodules of pathologically proven 392 malignant nodules were 169 (43%)
nodules. They include 12 (50%) of 24 cases of follicular carcinoma and 157 (44%) of 358 cases of papillary carcinoma.
Of 12 follicular carcinoma, 2 malignant features were found in 5 nodules, 1 malignant feature in 3 nodules, no malignant
feature in 4 nodules. Of 157 papillary carcinoma, 2 malignant features in 76 nodules, 1 malignant feature in 37 nodules,
no malignant feature in 44 nodules. Every medullary carcinoma and anaplastic carcinoma showed malignant features.
Conclusion: Our results showed that malignant thyroid nodules could be appear as benign or not definitely malignant nodules when we apply the reported sonographic criteria of malignant nodules. Ultrasonography guided fine-needle aspiration or core biopsy may be the valuable tool for sonographically benign-looking thyroid nodules for early diagnosis and treatment.
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KEYWORD
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Thyroid, Neoplasm, Ultasonograpy, Fine-needle aspiration biopsy
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